Combination synergy analysis was performed with the help of Cytoscape network analyzer tool with neighbourhood approach. The networks were constructed using Cytoscape 3.2.1. Databases- Binding DB, DAVID, KEGG and STRING were used to gather information to develop the networks. Oral bioavailability and drug likeness was screened for all the compounds. (TFHE) was subjected to LC-MS/MS analysis to identify the active constituents. LC-MS/MS based metabolite screening followed by ADME screening and finally network pharmacology exploration of the mechanism of action involved against hyperlipidemia and hypolipidemia with neighbourhood based combination synergy approach.Įthanolic extract of Trigonella foenum-graecum L. We aimed to explore the metabolites present in the plant extract and to establish the combination synergy and the network pharmacology along with the underlying the mechanism of action involved. It is also useful in obesity and reduces lipid level of blood. (Methika in Sanskrit) is a well known kaphahara (balancing kapha) herb in Ayurveda indicated in Prameha or early diabetes mellitus. json () new_suid = res_dict # Apply layout requests. dumps ( small_network ), headers = HEADERS ) res_dict = res. post ( BASE + 'networks?collection=My%20Collection', data = json. deepcopy ( empty_network ) # Sequence of letters (a-z) seq_letters = list ( map ( chr, range ( ord ( 'a' ), ord ( 'z' ) + 1 ))) # Build nodes and edges (in functional way) build_node = lambda x : rand_edges = list ( map ( build_edge, seq_letters )) small_network = abc_nodes small_network = rand_edges small_network = 'A is the hub.' # Uncomment this if you want to see the actual JSON object #print(json.dumps(small_network, indent=4)) res = requests. Import copy # Create a copy of the empty network object small_network = copy. To change this, you need set a global Cytoscape property from: Change Port Numberīy default, port number used by cyREST is 1234. In that case, you need to change the URL to the machine running Cytoscape desktop. Of course, you can run Cytoscape and IPython server on different machines. Once the final release is ready, we guarantee compatibility of your scripts as long as major version number is the same. To access Cytoscape REST API, use the following URL: where v1 is the current version number of API. We assume you are running Cytoscape desktop application and IPython Notebook server on a same machine. Basic Setup for the APIĪt this point, there is only one option for the cy-rest module: port number. Python has built-in support for JSON and we will use it in this workflow. JSON Encoding and Decodingĭata will be exchanged as JSON between Cytoscape and Python code. In this example, we use Requests library to simplify API call code. Since you need to access Cytoscape via RESTful API, HTTP client library is the most important tool you need to understand. In this tutorial, we will use several popular Python libraries to make this workflow more realistic. Import Python Libraries and Basic Setup Libraries
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